The MedMain goal is to advance engineering science and technology to enhance healthcare. Specifically, MedMain applies advanced robotics, manufacturing, and design for safety, quality, efficiency, and economy in healthcare service and research. MedMain balances fundamental science and clinical applications, producing research articles and patents, scientists, and entrepreneurs. Some representative projects are high-speed grinding inside human arteries to clear the blockage and treat cardiovascular diseases, high-speed machining of a blood clot inside the human brain to treat stroke, a tele-ultrasound imaging system with intuitive user interfaces, robotic catheterization for neuro intervention, mechanical testing of a blood clot, atherosclerotic plaque, and brain tissues, hydrodynamic polishing for 3D printed internal channels. MedMain has been extensively collaborating with healthcare organizations and medical schools nationwide including Beth Israel Deaconess Medical Center, Mayo Clinic, VA Ann Arbor Healthcare System, Saint Vincent Hospital, University of Massachusetts Medical School, University of Michigan Medical School, and Massachusetts College of Pharmacy and Health Sciences. MedMain has also worked with medical device companies including Boston Scientific, Cardiovascular Systems Inc., Endovascular Engineering, and Calcium Solutions.