diff --git a/setup.py b/setup.py
index 7cd77257ae35df..b6bd361a32c8d7 100644
--- a/setup.py
+++ b/setup.py
@@ -634,7 +634,8 @@ def add_ldflags_cppflags(self):
         for env_var, arg_name, dir_list in (
                 ('LDFLAGS', '-R', self.compiler.runtime_library_dirs),
                 ('LDFLAGS', '-L', self.compiler.library_dirs),
-                ('CPPFLAGS', '-I', self.compiler.include_dirs)):
+                ('CPPFLAGS', '-I', self.compiler.include_dirs),
+                ('CPPFLAGS', '-isystem', self.compiler.include_dirs)):
             env_val = sysconfig.get_config_var(env_var)
             if env_val:
                 parser = argparse.ArgumentParser()