diff --git a/.github/workflows/upstream-dev-ci.yaml b/.github/workflows/upstream-dev-ci.yaml
index c7ccee73414..ff7b633fcff 100644
--- a/.github/workflows/upstream-dev-ci.yaml
+++ b/.github/workflows/upstream-dev-ci.yaml
@@ -6,6 +6,7 @@ on:
   pull_request:
     branches:
       - main
+    types: [opened, reopened, synchronize, labeled]
   schedule:
     - cron: "0 0 * * *" # Daily “At 00:00” UTC
   workflow_dispatch: # allows you to trigger the workflow run manually
@@ -41,6 +42,7 @@ jobs:
         && (
             (github.event_name == 'schedule' || github.event_name == 'workflow_dispatch')
             || needs.detect-ci-trigger.outputs.triggered == 'true'
+            || contains( github.event.pull_request.labels.*.name, 'run-upstream')
         )
     defaults:
       run:
@@ -92,3 +94,58 @@ jobs:
         uses: xarray-contrib/issue-from-pytest-log@v1
         with:
           log-path: output-${{ matrix.python-version }}-log.jsonl
+
+  mypy-upstream-dev:
+    name: mypy-upstream-dev
+    runs-on: ubuntu-latest
+    needs: detect-ci-trigger
+    if: |
+        always()
+        && (
+            contains( github.event.pull_request.labels.*.name, 'run-upstream')
+        )
+    defaults:
+      run:
+        shell: bash -l {0}
+    strategy:
+      fail-fast: false
+      matrix:
+        python-version: ["3.10"]
+    steps:
+      - uses: actions/checkout@v3
+        with:
+          fetch-depth: 0 # Fetch all history for all branches and tags.
+      - name: Set up conda environment
+        uses: mamba-org/provision-with-micromamba@v15
+        with:
+          environment-file: ci/requirements/environment.yml
+          environment-name: xarray-tests
+          extra-specs: |
+            python=${{ matrix.python-version }}
+            pytest-reportlog
+            conda
+      - name: Install upstream versions
+        run: |
+          bash ci/install-upstream-wheels.sh
+      - name: Install xarray
+        run: |
+          python -m pip install --no-deps -e .
+      - name: Version info
+        run: |
+          conda info -a
+          conda list
+          python xarray/util/print_versions.py
+      - name: Install mypy
+        run: |
+          python -m pip install mypy --force-reinstall
+      - name: Run mypy
+        run: |
+          python -m mypy --install-types --non-interactive --cobertura-xml-report mypy_report
+      - name: Upload mypy coverage to Codecov
+        uses: codecov/codecov-action@v3.1.3
+        with:
+          file: mypy_report/cobertura.xml
+          flags: mypy
+          env_vars: PYTHON_VERSION
+          name: codecov-umbrella
+          fail_ci_if_error: false