diff --git a/libraries/SPI/src/utility/spi_com.c b/libraries/SPI/src/utility/spi_com.c
index a0b554a..b3c46bb 100644
--- a/libraries/SPI/src/utility/spi_com.c
+++ b/libraries/SPI/src/utility/spi_com.c
@@ -239,7 +239,7 @@ void spi_init(spi_t *obj, uint32_t speed, spi_mode_e mode, uint8_t msb)
   // Enable SPI clock
   if (handle->Instance == SPI1) 
   {
-    #if defined(CH32L10x)
+    #if defined(CH32L10x) || defined(CH32VM00X)
     RCC_PB2PeriphResetCmd(RCC_PB2Periph_SPI1, ENABLE);
     RCC_PB2PeriphResetCmd(RCC_PB2Periph_SPI1, DISABLE);
     RCC_PB2PeriphClockCmd(RCC_PB2Periph_SPI1, ENABLE );
@@ -254,7 +254,7 @@ void spi_init(spi_t *obj, uint32_t speed, spi_mode_e mode, uint8_t msb)
 #if defined SPI2_BASE
   if (handle->Instance == SPI2) 
   {
-    #if defined(CH32L10x)
+    #if defined(CH32L10x) || defined(CH32VM00X)
     RCC_PB1PeriphResetCmd(RCC_PB1Periph_SPI2, ENABLE);
     RCC_PB1PeriphResetCmd(RCC_PB1Periph_SPI2, DISABLE);
     RCC_PB1PeriphClockCmd(RCC_PB1Periph_SPI2, ENABLE );
@@ -269,7 +269,7 @@ void spi_init(spi_t *obj, uint32_t speed, spi_mode_e mode, uint8_t msb)
 #if defined SPI3_BASE
   if (handle->Instance == SPI3) 
   {
-    #if defined(CH32L10x)
+    #if defined(CH32L10x) || defined(CH32VM00X)
     RCC_PB1PeriphResetCmd(RCC_PB1Periph_SPI3, ENABLE);
     RCC_PB1PeriphResetCmd(RCC_PB1Periph_SPI3, DISABLE);
     RCC_PB1PeriphClockCmd(RCC_PB1Periph_SPI3, ENABLE );
@@ -306,7 +306,7 @@ void spi_deinit(spi_t *obj)
   // Reset SPI and disable clock
   if (handle->Instance == SPI1) 
   {
-    #if defined(CH32L10x)
+    #if defined(CH32L10x) || defined(CH32VM00X)
     RCC_PB2PeriphResetCmd(RCC_PB2Periph_SPI1, ENABLE);
     RCC_PB2PeriphResetCmd(RCC_PB2Periph_SPI1, DISABLE);
     RCC_PB2PeriphClockCmd(RCC_PB2Periph_SPI1, DISABLE);
@@ -320,7 +320,7 @@ void spi_deinit(spi_t *obj)
 #if defined SPI2_BASE
   if (handle->Instance == SPI2) 
   {
-    #if defined(CH32L10x)
+    #if defined(CH32L10x) || defined(CH32VM00X)
     RCC_PB1PeriphResetCmd(RCC_PB1Periph_SPI2, ENABLE);
     RCC_PB1PeriphResetCmd(RCC_PB1Periph_SPI2, DISABLE);
     RCC_PB1PeriphClockCmd(RCC_PB1Periph_SPI2, DISABLE);
@@ -335,7 +335,7 @@ void spi_deinit(spi_t *obj)
 #if defined SPI3_BASE
   if (handle->Instance == SPI3) 
   {
-    #if defined(CH32L10x)
+    #if defined(CH32L10x) || defined(CH32VM00X)
     RCC_PB1PeriphResetCmd(RCC_PB1Periph_SPI3, ENABLE);
     RCC_PB1PeriphResetCmd(RCC_PB1Periph_SPI3, DISABLE);
     RCC_PB1PeriphClockCmd(RCC_PB1Periph_SPI3, DISABLE);
diff --git a/libraries/Wire/src/utility/twi.c b/libraries/Wire/src/utility/twi.c
index 7b65983..2948fc4 100644
--- a/libraries/Wire/src/utility/twi.c
+++ b/libraries/Wire/src/utility/twi.c
@@ -141,9 +141,15 @@ void i2c_custom_init(i2c_t *obj, uint32_t timing, uint32_t addressingMode, uint3
         // Enable I2C1 clock if not done
         if (obj->i2c == I2C1) 
         {
+          #if defined(CH32L10x) || defined(CH32VM00X)
+          RCC_PB1PeriphResetCmd(RCC_PB1Periph_I2C1, ENABLE);
+          RCC_PB1PeriphResetCmd(RCC_PB1Periph_I2C1, DISABLE);
+          RCC_PB1PeriphClockCmd(RCC_PB1Periph_I2C1, ENABLE );
+          #else
           RCC_APB1PeriphResetCmd(RCC_APB1Periph_I2C1, ENABLE);
           RCC_APB1PeriphResetCmd(RCC_APB1Periph_I2C1, DISABLE);
           RCC_APB1PeriphClockCmd(RCC_APB1Periph_I2C1, ENABLE );
+          #endif
 
           obj->irq = I2C1_EV_IRQn;
           obj->irqER = I2C1_ER_IRQn;
@@ -154,9 +160,15 @@ void i2c_custom_init(i2c_t *obj, uint32_t timing, uint32_t addressingMode, uint3
         // Enable I2C2 clock if not done
         if (obj->i2c == I2C2) 
         {
+          #if defined(CH32L10x) || defined(CH32VM00X)
+          RCC_PB1PeriphResetCmd(RCC_PB1Periph_I2C2, ENABLE);
+          RCC_PB1PeriphResetCmd(RCC_PB1Periph_I2C2, DISABLE);
+          RCC_PB1PeriphClockCmd(RCC_PB1Periph_I2C2, ENABLE );
+          #else
           RCC_APB1PeriphResetCmd(RCC_APB1Periph_I2C2, ENABLE);
           RCC_APB1PeriphResetCmd(RCC_APB1Periph_I2C2, DISABLE);
           RCC_APB1PeriphClockCmd(RCC_APB1Periph_I2C2, ENABLE );
+          #endif
 
           obj->irq = I2C2_EV_IRQn;
           obj->irqER = I2C2_ER_IRQn;