diff --git a/llvm/lib/Transforms/Vectorize/LoopVectorize.cpp b/llvm/lib/Transforms/Vectorize/LoopVectorize.cpp
index f4259d3d69880..3d657cdf254ca 100644
--- a/llvm/lib/Transforms/Vectorize/LoopVectorize.cpp
+++ b/llvm/lib/Transforms/Vectorize/LoopVectorize.cpp
@@ -10101,6 +10101,13 @@ bool LoopVectorizePass::processLoop(Loop *L) {
   // Get user vectorization factor and interleave count.
   ElementCount UserVF = Hints.getWidth();
   unsigned UserIC = Hints.getInterleave();
+  if (LVL.hasUncountableEarlyExit() && UserIC != 1 &&
+      !VectorizerParams::isInterleaveForced()) {
+    UserIC = 1;
+    reportVectorizationInfo("Interleaving not supported for loops "
+                            "with uncountable early exits",
+                            "InterleaveEarlyExitDisabled", ORE, L);
+  }
 
   // Plan how to best vectorize.
   LVP.plan(UserVF, UserIC);
diff --git a/llvm/test/Transforms/LoopVectorize/single-early-exit-interleave-hint.ll b/llvm/test/Transforms/LoopVectorize/single-early-exit-interleave-hint.ll
new file mode 100644
index 0000000000000..7e9778e4c4262
--- /dev/null
+++ b/llvm/test/Transforms/LoopVectorize/single-early-exit-interleave-hint.ll
@@ -0,0 +1,88 @@
+; NOTE: Assertions have been autogenerated by utils/update_test_checks.py UTC_ARGS: --version 5
+; RUN: opt -p loop-vectorize -enable-early-exit-vectorization -force-vector-width=4 \
+; RUN:   -debug-only=loop-vectorize -S %s 2>%t | FileCheck --check-prefix=VF4IC4 %s
+; RUN: cat %t | FileCheck --check-prefix=DEBUG %s
+
+declare void @init_mem(ptr, i64);
+
+; DEBUG: Interleaving not supported for loops with uncountable early exits
+
+define i64 @multi_exiting_to_different_exits_live_in_exit_values() {
+; VF4IC4-LABEL: define i64 @multi_exiting_to_different_exits_live_in_exit_values() {
+; VF4IC4-NEXT:  [[ENTRY:.*]]:
+; VF4IC4-NEXT:    [[SRC:%.*]] = alloca [128 x i32], align 4
+; VF4IC4-NEXT:    call void @init_mem(ptr [[SRC]])
+; VF4IC4-NEXT:    br i1 false, label %[[SCALAR_PH:.*]], label %[[VECTOR_PH:.*]]
+; VF4IC4:       [[VECTOR_PH]]:
+; VF4IC4-NEXT:    br label %[[VECTOR_BODY:.*]]
+; VF4IC4:       [[VECTOR_BODY]]:
+; VF4IC4-NEXT:    [[INDEX:%.*]] = phi i64 [ 0, %[[VECTOR_PH]] ], [ [[INDEX_NEXT:%.*]], %[[VECTOR_BODY]] ]
+; VF4IC4-NEXT:    [[TMP0:%.*]] = getelementptr inbounds i32, ptr [[SRC]], i64 [[INDEX]]
+; VF4IC4-NEXT:    [[TMP1:%.*]] = getelementptr inbounds i32, ptr [[TMP0]], i32 0
+; VF4IC4-NEXT:    [[WIDE_LOAD:%.*]] = load <4 x i32>, ptr [[TMP1]], align 4
+; VF4IC4-NEXT:    [[TMP2:%.*]] = icmp eq <4 x i32> [[WIDE_LOAD]], splat (i32 10)
+; VF4IC4-NEXT:    [[INDEX_NEXT]] = add nuw i64 [[INDEX]], 4
+; VF4IC4-NEXT:    [[TMP3:%.*]] = call i1 @llvm.vector.reduce.or.v4i1(<4 x i1> [[TMP2]])
+; VF4IC4-NEXT:    [[TMP4:%.*]] = icmp eq i64 [[INDEX_NEXT]], 128
+; VF4IC4-NEXT:    [[TMP5:%.*]] = or i1 [[TMP3]], [[TMP4]]
+; VF4IC4-NEXT:    br i1 [[TMP5]], label %[[MIDDLE_SPLIT:.*]], label %[[VECTOR_BODY]], !llvm.loop [[LOOP0:![0-9]+]]
+; VF4IC4:       [[MIDDLE_SPLIT]]:
+; VF4IC4-NEXT:    br i1 [[TMP3]], label %[[VECTOR_EARLY_EXIT:.*]], label %[[MIDDLE_BLOCK:.*]]
+; VF4IC4:       [[MIDDLE_BLOCK]]:
+; VF4IC4-NEXT:    br i1 true, label %[[E2:.*]], label %[[SCALAR_PH]]
+; VF4IC4:       [[VECTOR_EARLY_EXIT]]:
+; VF4IC4-NEXT:    br label %[[E1:.*]]
+; VF4IC4:       [[SCALAR_PH]]:
+; VF4IC4-NEXT:    [[BC_RESUME_VAL:%.*]] = phi i64 [ 128, %[[MIDDLE_BLOCK]] ], [ 0, %[[ENTRY]] ]
+; VF4IC4-NEXT:    br label %[[LOOP_HEADER:.*]]
+; VF4IC4:       [[LOOP_HEADER]]:
+; VF4IC4-NEXT:    [[IV:%.*]] = phi i64 [ [[INC:%.*]], %[[LOOP_LATCH:.*]] ], [ [[BC_RESUME_VAL]], %[[SCALAR_PH]] ]
+; VF4IC4-NEXT:    [[GEP_SRC:%.*]] = getelementptr inbounds i32, ptr [[SRC]], i64 [[IV]]
+; VF4IC4-NEXT:    [[L:%.*]] = load i32, ptr [[GEP_SRC]], align 4
+; VF4IC4-NEXT:    [[C_1:%.*]] = icmp eq i32 [[L]], 10
+; VF4IC4-NEXT:    br i1 [[C_1]], label %[[E1]], label %[[LOOP_LATCH]]
+; VF4IC4:       [[LOOP_LATCH]]:
+; VF4IC4-NEXT:    [[INC]] = add nuw i64 [[IV]], 1
+; VF4IC4-NEXT:    [[C_2:%.*]] = icmp eq i64 [[INC]], 128
+; VF4IC4-NEXT:    br i1 [[C_2]], label %[[E2]], label %[[LOOP_HEADER]], !llvm.loop [[LOOP3:![0-9]+]]
+; VF4IC4:       [[E1]]:
+; VF4IC4-NEXT:    [[P1:%.*]] = phi i64 [ 0, %[[LOOP_HEADER]] ], [ 0, %[[VECTOR_EARLY_EXIT]] ]
+; VF4IC4-NEXT:    ret i64 [[P1]]
+; VF4IC4:       [[E2]]:
+; VF4IC4-NEXT:    [[P2:%.*]] = phi i64 [ 1, %[[LOOP_LATCH]] ], [ 1, %[[MIDDLE_BLOCK]] ]
+; VF4IC4-NEXT:    ret i64 [[P2]]
+;
+entry:
+  %src = alloca [128 x i32]
+  call void @init_mem(ptr %src)
+  br label %loop.header
+
+loop.header:
+  %iv = phi i64 [ %inc, %loop.latch ], [ 0, %entry ]
+  %gep.src = getelementptr inbounds i32, ptr %src, i64 %iv
+  %l = load i32, ptr %gep.src
+  %c.1 = icmp eq i32 %l, 10
+  br i1 %c.1, label %e1, label %loop.latch
+
+loop.latch:
+  %inc = add nuw i64 %iv, 1
+  %c.2 = icmp eq i64 %inc, 128
+  br i1 %c.2, label %e2, label %loop.header, !llvm.loop !0
+
+e1:
+  %p1 = phi i64 [ 0, %loop.header ]
+  ret i64 %p1
+
+e2:
+  %p2 = phi i64 [ 1, %loop.latch ]
+  ret i64 %p2
+}
+
+!0 = distinct !{!0, !1}
+!1 = !{!"llvm.loop.interleave.count", i32 4}
+;.
+; VF4IC4: [[LOOP0]] = distinct !{[[LOOP0]], [[META1:![0-9]+]], [[META2:![0-9]+]]}
+; VF4IC4: [[META1]] = !{!"llvm.loop.isvectorized", i32 1}
+; VF4IC4: [[META2]] = !{!"llvm.loop.unroll.runtime.disable"}
+; VF4IC4: [[LOOP3]] = distinct !{[[LOOP3]], [[META2]], [[META1]]}
+;.